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pai 039  (Pfizer Inc)

 
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    Structured Review

    Pfizer Inc pai 039
    Pai 039, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pai+039/pm42030999-158-4-7?v=Pfizer+Inc
    Average 86 stars, based on 1 article reviews
    pai 039 - by Bioz Stars, 2026-06
    86/100 stars

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    EGCG decreased H 2 O 2 ‐induced extracellular matrix protein turnover‐related targeted proteins expressions in MAVSMCs treated with PAI‐1 inhibitor and plPAI‐1. (A, B) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 <t>+</t> <t>PAI‐039,</t> H 2 O 2 + PAI‐039 + EGCG groups ( n = 3/group). (C, D) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 + pl‐PAI‐1, H 2 O 2 + EGCG groups ( n = 3/group). Data are mean ± SEM. Statistical significance was assessed by 1‐way ANOVA for B and D. NC indicates negative control. PAI‐039 indicates PAI‐1 inhibitor. pl‐PAI‐1 indicates PAI‐1 overexpression.
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    EGCG decreased H 2 O 2 ‐induced extracellular matrix protein turnover‐related targeted proteins expressions in MAVSMCs treated with PAI‐1 inhibitor and plPAI‐1. (A, B) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 <t>+</t> <t>PAI‐039,</t> H 2 O 2 + PAI‐039 + EGCG groups ( n = 3/group). (C, D) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 + pl‐PAI‐1, H 2 O 2 + EGCG groups ( n = 3/group). Data are mean ± SEM. Statistical significance was assessed by 1‐way ANOVA for B and D. NC indicates negative control. PAI‐039 indicates PAI‐1 inhibitor. pl‐PAI‐1 indicates PAI‐1 overexpression.
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    EGCG decreased H 2 O 2 ‐induced extracellular matrix protein turnover‐related targeted proteins expressions in MAVSMCs treated with PAI‐1 inhibitor and plPAI‐1. (A, B) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 + PAI‐039, H 2 O 2 + PAI‐039 + EGCG groups ( n = 3/group). (C, D) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 + pl‐PAI‐1, H 2 O 2 + EGCG groups ( n = 3/group). Data are mean ± SEM. Statistical significance was assessed by 1‐way ANOVA for B and D. NC indicates negative control. PAI‐039 indicates PAI‐1 inhibitor. pl‐PAI‐1 indicates PAI‐1 overexpression.

    Journal: The FASEB Journal

    Article Title: Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF ‐β/Smad2/3 Signaling in Mice

    doi: 10.1096/fj.202403133RR

    Figure Lengend Snippet: EGCG decreased H 2 O 2 ‐induced extracellular matrix protein turnover‐related targeted proteins expressions in MAVSMCs treated with PAI‐1 inhibitor and plPAI‐1. (A, B) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 + PAI‐039, H 2 O 2 + PAI‐039 + EGCG groups ( n = 3/group). (C, D) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 + pl‐PAI‐1, H 2 O 2 + EGCG groups ( n = 3/group). Data are mean ± SEM. Statistical significance was assessed by 1‐way ANOVA for B and D. NC indicates negative control. PAI‐039 indicates PAI‐1 inhibitor. pl‐PAI‐1 indicates PAI‐1 overexpression.

    Article Snippet: Tiplaxtinin (PAI‐039, APExBIO, Houston, USA) known as a PAI‐1 inhibitor was applied to VSMC experiments at indicated concentration (10 μM).

    Techniques: Western Blot, Negative Control, Over Expression